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CYP2B6 is An important CYP enzyme involved with the metabolism of S-methadone and to an extent, R-methadone. The expression of CYP2B6Benzodiazepines: May improve the CNS depressant effect of Methadone. Management: Clinicians should really commonly keep away from concurrent use of methadone and benzodiazepines when attainable; any combined use reall